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KMID : 0613820160260020259
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Journal of Life Science
2016 Volume.26 No. 2 p.259 ~ p.264
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Anti-metastatic Effect of Garlic Hexane Extract on Lung Metastasis Induced by Melanoma B16F10 Cells in Mice
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Ko Min-Jung
Rajasekar Seetharaman
Wang Zi-Yu
Li Mei
Kwak Jung-Ho
Park Young-Hoon
Son Beung-Gu
Kang Jum-Soon
Choi Young-Whan
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Abstract
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Metastatic cancer is one of the main causes of cancer-related death since they rarely respond to available treatments. There is epidemiologic evidence that high garlic consumption decreases the incidence of cancer. Recent studies of our laboratory have revealed that a garlic-extracts is effective in suppressing metastasis. For experimental metastasis, C57BL/6 mice were injected intravenously with melanoma B16F10 cells in the tail vein, and were orally administered various concentrations (0, 50, 100 or 200 mg/kg body weight) of garlic hexane extract (GHE) for 21 days. The incidence and the area of the melanoma cell colony occupied by the poorly differentiated carcinoma were significantly lower in dose-dependent in 50, 100 and 200 mg/kg BW GHE?treated mice compared with control mice. In conclusion, the results of the present study show that GHE administration prevents lung metastasis in C57BL/6 mice.
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KEYWORD
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C57BL/6 mice, garlic hexane extract, melanoma B16F10, metastasis
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